Friday, May 15, 2020

The And Its Effects On Alzheimer s Disease Essay

According to the Alzheimer’s Association (AA), â€Å"more than 5 million Americans are living with Alzheimer’s disease† and this number is expected to triple by the year 2050. The AA website states that Alzheimer’s is the 6th leading cause of death in our country with 1 in 3 seniors dying from Alzheimer’s or other types of dementia. Because this disease effects so many people and because its symptoms are so devastating, scientists are continually searching for the cause of Alzheimer’s disease (AD) in attempt to find treatment or a cure. Some scientists working in this field believe that microbial infections may be underlying causes of the disease. There are many theories and studies are being conducted to determine whether bacteria or viruses are playing some role in the development of AD and other forms of dementia. To understand how microbes may be involved in AD, we first must look at what physically happens to the brain with this disease. There are two distinct aspects involved in Alzheimer’s disease; beta-amyloid plaques and tau tangles. Beta-amyloid plaques are formed when the amyloid precursor protein (APP) which is present in the membrane of neurons (alz.org) is cleaved off by beta and gamma-secretases (Chen et al., 2001). In a normal brain, alpha-secretase does the cleaving and the body processes APP on its own (Chen, et al., 2001). In AD, the small pieces join to form beta-amyloid plaques but as smaller individual pieces they can interfere with nerve signalingShow MoreRelatedAlzheimer s Disease And Its Effects932 Words   |  4 PagesAlzheimer’s disease Alzheimer’s disease is a mental disorder that catches up to many while in middle or old age, due to generalized degeneration of the brain. It is the most common cause of premature senility. What causes this disease? Experts believe that Alzheimer s develops as a complex result of multiple factors rather than any one overriding cause. 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